What is the impact of FBX-PG on the bioavailability of Febuxostat in rats and mice?

Label:chem

Topic
Bioavailability is a critical factor in determining the efficacy of a drug. A study evaluated the pharmacokinetic properties of FBX-PG compared to FBX alone in rats and mice.
Answer
The bioavailability (F) of Febuxostat was significantly higher in rats and mice treated with FBX-PG compared to those treated with FBX alone. In rats, the relative bioavailability of FBX-PG was 210%, and in mice, it was 159%. This indicates that FBX-PG enhances the absorption and systemic exposure of FBX.
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