How does the solubility of Febuxostat (FBX) compare to that of the FBX-PG cocrystal?

Label:chem

Topic
Febuxostat is a poorly water-soluble drug classified under BCS class II, which limits its absorption and bioavailability. Enhancing its solubility is crucial for improving its therapeutic efficacy.
Answer
The solubility of Febuxostat (FBX) is significantly lower than that of the FBX-PG cocrystal. The FBX-PG cocrystal shows a 4-fold increase in solubility compared to FBX alone, making it more effective for improving oral bioavailability.
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