How does L-pyroglutamic acid affect the expression of Tri genes in F. graminearum?

Label:chem

Topic
The Tri genes (Tri4, Tri5, and Tri10) are essential for the biosynthesis of trichothecenes, which are toxic secondary metabolites produced by F. graminearum. Understanding the impact of L-pyroglutamic acid on these genes can provide insights into its antifungal mechanism.
Answer
L-pyroglutamic acid inhibits the expression of Tri4, Tri5, and Tri10 genes, thereby reducing trichothecene production. The inhibition is observed at transcriptional levels, with significant effects noted at higher concentrations of L-pyroglutamic acid (400 and 800 µg/g).
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