How does the in vitro metabolism of pectenotoxin-2 (PTX-2) in rat hepatocytes affect its oral toxicity?

Label:chem

Topic
PTX-2 has been shown to have low oral toxicity in vivo, which may be due to its rapid metabolism and biotransformation in the liver.
Answer
The rapid oxidative metabolism of PTX-2 in rat hepatocytes, forming oxidized metabolites, likely contributes to its low oral toxicity by reducing the amount of the parent toxin that reaches systemic circulation.
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