How does flutamide affect the formation of hepatic preneoplastic lesions in rats fed a high-fat diet?

Label:chem

Topic
Hepatic preneoplastic lesions are early indicators of hepatocarcinogenesis. A study investigated the effects of flutamide on the formation and characteristics of these lesions in rats fed a high-fat diet.
Answer
Flutamide treatment resulted in a marginal increase in the number and area of glutathione S-transferase placental form (GST-P)-positive foci, indicating preneoplastic lesions. Studies also found that flutamide counteracted HFD-induced mitophagy inhibition, which could potentially contribute to the maintenance and progression of these lesions. This suggests that flutamide may enhance the risk of hepatocarcinogenesis by affecting mitophagy and promoting the formation of preneoplastic lesions.
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