How do the SDNE-WDSs enhance the intestinal permeability of zanamivir?

Label:chem

Topic
A study investigates the ability of SDNE-WDSs to improve the transport of zanamivir across intestinal membranes using both in vitro and in situ methods.
Answer
The SDNE-WDSs enhance intestinal permeability by encapsulating zanamivir within their structure, protecting it from degradation, and facilitating its transport across the intestinal membrane. Both formulations (SDNE-WDS1 and SDNE-WDS2) demonstrated effective permeability values (Peff) that were 3.5–5.5-fold higher than those of the low/high permeability boundary marker metoprolol.
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