What are the potential benefits of rapid TDM using HPLC-UV for voriconazole treatment in outpatients?

Label:chem

Topic
Voriconazole has nonlinear pharmacokinetics and a narrow therapeutic window, making TDM essential for optimizing treatment and preventing toxicity. However, delays in TDM results can hinder timely dose adjustments and increase the risk of adverse effects or treatment failure.
Answer
Rapid TDM using HPLC-UV allows for immediate feedback on voriconazole blood concentrations, enabling timely dose adjustments and improving patient safety. This method is cost-effective and can be implemented in medical facilities without the need for expensive equipment or expertise. It also helps in managing long-term treatments, such as those for chronic pulmonary aspergillosis, by ensuring therapeutic levels are maintained and reducing the risk of resistance development.
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