How do the antioxidant properties of the rivastigmine hybrids compare to those of the reference compounds?

Label:chem

Topic
Antioxidants play a crucial role in mitigating oxidative stress, which is a significant contributor to the progression of Alzheimer's disease (AD). A study evaluated the antioxidant capacity of rivastigmine hybrids using the DPPH method.
Answer
The rivastigmine hybrids incorporating Trolox (4AY2 and 4BY2) and catechol groups (4AY5 and 4AY6) exhibited high antioxidant activity, with EC50 values ranging from 15.7 to 28 μM. These values are comparable to the reference compound Trolox (EC50 = 13.8 μM). The syringic acid derivatives (4AY1, 4BY1, and 4CY1) and piperic acid derivatives (4AY3 and 4BY3) showed lower antioxidant activity, likely due to the absence of free phenolic hydroxyl groups.
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