What are the effects of flutamide on lipid metabolism and oxidative stress in the liver?

Label:chem

Topic
Lipid metabolism and oxidative stress are critical factors in the development and progression of NAFLD. A study evaluated the effects of flutamide on genes related to lipid metabolism and oxidative stress in the liver.
Answer
Flutamide treatment led to significant changes in lipid metabolism-related genes, including increased expression of Abca1 and Srebf2 in the HFD + FL group. Additionally, flutamide induced oxidative stress, as evidenced by increased expression of the antioxidant enzyme Gpx2. These findings suggest that flutamide can alter lipid metabolism and induce oxidative stress, which may contribute to the progression of NAFLD and hepatocarcinogenesis.
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