How does flutamide affect early hepatocarcinogenesis in high-fat diet-fed non-obese steatotic rats?

Label:chem

Topic
Flutamide (FL) is a non-steroidal antiandrogenic and anticancer drug known for its mitochondrial toxicity and potential to induce hepatocarcinogenesis. A study investigates its effects on early hepatocarcinogenesis in rats fed a high-fat diet (HFD), which is known to induce non-alcoholic fatty liver disease (NAFLD).
Answer
Flutamide exacerbates HFD-induced steatosis and marginally increases preneoplastic lesions in rats. It counteracts HFD-mediated mitophagy inhibition, as indicated by increased LC3 and decreased AMBRA1 levels in background hepatocytes. This suggests that FL-induced mitophagy induction relies on Parkin expression and may potentially exacerbate NAFLD-associated hepatocarcinogenesis by affecting mitophagy.
Return to Home Chemical List
Knowledge you may be interested in
How did the rivastigmine hybrids perform in cell viability and neuroprotective assays? What are the pharmacokinetic properties of the rivastigmine hybrids, and how do they compare to rivastigmine? What insights did molecular docking studies provide regarding the binding of rivastigmine hybrids to cholinesterases? How effective are the rivastigmine hybrids in inhibiting Aβ1–42 aggregation? What is the impact of structural modifications on the cholinesterase inhibitory activity of rivastigmine hybrids? How do the antioxidant properties of the rivastigmine hybrids compare to those of the reference compounds? What are the key findings regarding the multifunctional properties of rivastigmine hybrids in the context of Alzheimer's disease (AD) therapy? How does the presence of amines affect the productivity of polypropylene polymerization in industrial settings? What are the structural characteristics of DMA and DEA that influence their interaction with the Ziegler–Natta catalyst? How do the adsorption energies of TEAL·DMA and TEAL·DEA on the Ziegler–Natta catalyst surface compare? How does flutamide influence the expression of autophagy and mitophagy-related genes in the liver? What are the effects of flutamide on lipid metabolism and oxidative stress in the liver? How does flutamide affect the formation of hepatic preneoplastic lesions in rats fed a high-fat diet? How does post-deposition recrystallization with indium bromide affect the structural and electrical properties of Cu(In,Ga)Se2 (CIGS) thin films? What changes in elemental composition are observed in CIGS films after recrystallization with indium bromide? What are the implications of the changes in gallium profile and sodium content in CIGS films after InBr3 recrystallization for device performance? What are the potential benefits of rapid TDM using HPLC-UV for voriconazole treatment in outpatients? What is the primary goal of developing the Self-Double Nanoemulsifying Winsor Delivery System (SDNE-WDS) for zanamivir? How do the SDNE-WDSs enhance the intestinal permeability of zanamivir? What are the average droplet sizes of the zanamivir-loaded SDNE-WDSs after self-emulsification?