How did the rivastigmine hybrids perform in cell viability and neuroprotective assays?

Label:chem

Topic
Assessing the neuroprotective effects of rivastigmine hybrids against oxidative stress and Aβ-induced toxicity is crucial for evaluating their potential therapeutic application in AD.
Answer
The rivastigmine hybrids were tested for their protective effects against oxidative stress induced by iron/ascorbate and Aβ1–42. Compounds 4AY2, 4AY4, and 4BY2 showed significant neuroprotective effects against oxidative stress, restoring cell viability to levels close to untreated controls. However, none of the tested compounds were able to prevent cytotoxicity induced by Aβ1–42. These findings highlight the potential of these hybrids to modulate mitochondrial or redox homeostasis, although further studies are needed to elucidate their mechanisms of action.
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