What were the results of the in vitro release studies of zanamivir from the SDNE-WDSs compared to free zanamivir?

Label:chem

Topic
A study compared the release profiles of zanamivir from the SDNE-WDSs to those of free zanamivir to evaluate the controlled release capabilities of the delivery system.
Answer
The in vitro release studies showed that zanamivir-loaded SDNE-WDSs exhibited a more controlled release pattern compared to free zanamivir. After 4 hours, the cumulative release of zanamivir from SDNE-WDS1 and SDNE-WDS2 reached 86.1% and 81.6%, respectively, while free zanamivir showed a rapid burst release of approximately 59% within the first 20 minutes.
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