How does flutamide influence the expression of autophagy and mitophagy-related genes in the liver?

Label:chem

Topic
Autophagy and mitophagy are essential processes for maintaining cellular health by removing damaged organelles and proteins. A study evaluated the effects of flutamide on autophagy and mitophagy-related gene expression in the liver of rats fed a high-fat diet.
Answer
A study found that flutamide significantly increased the expression of autophagy-related genes such as Atg5, Atg7, Lamp1, Lamp2, and Lc3 in the HFD + FL group compared to the HFD group alone. Additionally, flutamide increased the expression of mitophagy-related genes like Parkin and Ambra1, indicating an induction of mitophagy. This suggests that flutamide can modulate autophagy and mitophagy pathways, potentially contributing to its hepatocarcinogenic effects.
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