What is the significance of PTGS2 in the context of AHR modulation and gemcitabine response?

Label:chem

Topic
PTGS2 (prostaglandin-endoperoxide synthase-2) is a gene regulated by AHR activity. Its expression can be used as a marker to assess the effectiveness of AHR modulation by selective small-molecule inhibitors or activators.
Answer
PTGS2 expression is significantly affected by AHR modulation. Inhibition of AHR with BAY decreases PTGS2 mRNA and protein expression, while activation of AHR with tapinarof increases PTGS2 expression. This indicates that PTGS2 can serve as a reliable marker for assessing AHR activity in pancreatic cancer cells. The changes in PTGS2 expression correlate with the modulation of gemcitabine response, further supporting the role of AHR in chemoresistance.
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