What is the role of Dess–Martin periodinane (DMP) in the oxidative coupling reaction of isoquinoline with benzyl bromide?

Label:chem

Topic
Dess–Martin periodinane (DMP) is a hypervalent iodine reagent known for its ability to mediate oxidation reactions. A study explores its use in the oxidative coupling of isoquinoline with benzyl bromide to synthesize N-substituted isoquinolinone derivatives.
Answer
DMP acts as an efficient oxidant in the oxidative coupling reaction of isoquinoline with benzyl bromide, facilitating the formation of isoquinoline-1,3-dione or isoquinoline-1,3,4-trione derivatives under metal-free, mild, and practical conditions.
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