What is the role of vitamin D (Vit D) in skeletal muscle physiology?

Label:chem

Topic
Vitamin D is traditionally recognized for its role in calcium and phosphorus absorption and bone health, but recent research indicates broader functions.
Answer
Beyond its classical role in bone metabolism, vitamin D acts as a prohormone with pleiotropic effects, including modulation of gene expression in skeletal muscle via vitamin D receptors (VDRs). It regulates muscle protein synthesis, calcium homeostasis, mitochondrial function, and inflammatory signaling through genomic and non-genomic pathways.
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