Does relugolix combination therapy preserve BMD over extended treatment periods?

Label:chem

Topic
The LIBERTY and SPIRIT phase-III/III-extension studies enrolled premenopausal women with UFs or endometriosis to evaluate long-term safety.
Answer
DXA measurements over 24–104 weeks demonstrated that relugolix + E2/NETA maintained BMD within ±1 % of baseline (e.g., −0.8 % lumbar spine and −0.6 % total hip at 104 weeks), with values comparable to age-matched untreated controls, confirming skeletal safety for at least two years.
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