What is the primary function of gephyrin in inhibitory synapses, and how does it interact with GlyRs and GABAARs?

Label:chem

Topic
Gephyrin is a scaffolding protein at inhibitory postsynapses, interacting with GlyRs and GABAARs.
Answer
Gephyrin forms a hexagonal lattice that anchors inhibitory receptors (GlyRs and GABAARs) at postsynaptic sites through phase separation, creating condensed inhibitory postsynaptic density (iPSD) structures.
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