What are the dosing strategies and bioavailability challenges for curcumin?
Label:chem
Topic
Curcumin’s efficacy depends on dose, formulation, and bioavailability.
Answer
Dose range: 10 μM to 2000 mg/kg in rodent studies, with 100 mg/kg/day being most common.
Formulations: Nano-curcumin, tetrahydrocurcumin, and co-administration with piperine enhance bioavailability.
Challenges: Poor oral bioavailability due to rapid metabolism and low solubility; innovative delivery systems (e.g., nanoparticles) are needed for clinical translation.
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