How does strychnine affect GlyR clustering, and what are the limitations of using strychnine?

Label:chem

Topic
Strychnine is a competitive GlyR antagonist extracted from Strychnos nux vomica.
Answer
Strychnine blocks GlyR activation, reducing GlyR cluster number and size in a dose-dependent manner. However, prolonged strychnine exposure alters GlyR mRNA/protein levels, and high concentrations may affect other receptors, limiting its specificity.
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