What is diazepam’s pharmacological role in modulating epileptiform activity, and at what concentration was it tested?

Label:chem

Topic
Diazepam is a benzodiazepine that acts as a positive allosteric modulator of GABA_A receptors, increasing chloride conductance, hyperpolarizing neurons, and reducing excitability.
Answer
In the SH-SY5Y cell model, diazepam (14 μM) significantly lowered KCl-induced Ca²⁺ influx, decreasing the median fluorescence change (%∆F/F) from 24.80 (control) to 11.46, indicating reduced epileptiform activity.
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