How do cannabinoids influence bone healing, and what are the specific roles of CB1 and CB2 receptors?

Label:chem

Topic
Cannabinoids interact with the endocannabinoid system (ECS), which includes CB1 and CB2 receptors, to modulate skeletal metabolism and bone healing.
Answer
CB2 activation promotes osteogenesis by enhancing osteoblast activity and reducing osteoclast formation, while CB1 activation can have biphasic effects—beneficial at low doses but inhibitory at high doses, particularly with sustained THC exposure, which may impair bone healing.
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