How does gramicidin-D assist in membrane potential measurements?

Label:chem

Topic
Gramicidin-D is a peptide antibiotic known to form ion channels.
Answer
Gramicidin-D is used in the external calibration of the photomultiplier tube output for membrane potential measurements. By incorporating a large monovalent cation conductance into the cell membrane, it drives the membrane potential to approximately 0 mV when cells are suspended in a basic Na solution.
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