How does okadaic acid affect the CRAC entry pathway in rat basophilic leukemia cells?

Label:chem

Topic
Okadaic acid is a structurally unrelated phosphatase antagonist to calyculin A, also inhibiting type 1/2A phosphatase activity. Its effect on the CRAC entry pathway helps confirm the role of phosphatase activity.
Answer
Okadaic acid, a type 1/2A serine/threonine phosphatase inhibitor, inhibits the Ca2+ release-activated Ca2+ (CRAC) entry pathway in rat basophilic leukemia cells and also inhibits the depolarization that accompanies Ca2+ entry through this pathway.
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