Why is dihydroartemisinin (DHA) toxicity affected by free heme levels in leukemia?

Label:chem

Topic
DHA is an antimalarial drug whose mode of action is reliant upon heme. Low expression or loss of ABCB6 reduces porphyrins, leading to resistance to DHA in BCR-ABL+ cells.
Answer
Dihydroartemisinin (DHA) is an antimalarial drug with a mode of action reliant upon heme, and prior studies confirm that artemisinin drug toxicity is directly affected by free heme levels in leukemia.
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