How does succinylacetone (SA) affect hypoxic survival in cells overexpressing ABCB6?

Label:chem

Topic
SA is a potent inhibitor of aminolevulinic acid dehydratase (ALAD), a key porphyrin biosynthetic enzyme. Maximal porphyrin biosynthesis is required for optimal survival under hypoxia.
Answer
Succinylacetone (SA) eliminates the salutary effect of ABCB6 on hypoxic survival by inhibiting aminolevulinic acid dehydratase (ALAD), a key porphyrin biosynthetic enzyme, thereby preventing maximal porphyrin biosynthesis required for optimal survival under hypoxia.
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