What is the primary function of thapsigargin in experiments?

Label:chem

Topic

Thapsigargin is a commonly used pharmacological tool in calcium signaling research.

Answer

Thapsigargin is used to activate the Ca2+ release-activated Ca2+ (CRAC) entry pathway by depleting intracellular Ca2+ stores, leading to a biphasic rise in intracellular Ca2+ concentration and membrane depolarization.

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