How does gilvocarcin (GV) compare to 8-methoxypsoralen (8-MOP) in terms of potency and mechanism of action?

Label:chem

Topic
Both gilvocarcin (GV) and 8-methoxypsoralen (8-MOP) are used in photochemotherapy, but GV has been shown to be significantly more potent than 8-MOP. The study investigates the factors contributing to this difference in potency.
Answer
Gilvocarcin (GV) is 1170 times more potent than 8-methoxypsoralen (8-MOP) in inhibiting lymphocyte response to phytohemagglutinin stimulation. This increased potency is attributed to GV's stronger DNA intercalation ability (binding constant of 6.6×10^5 M^-1 compared to 8-MOP's 770 M^-1) and its more efficient absorption of UVA radiation. Additionally, GV's exocyclic vinyl group is essential for its photochemical activity, which is absent in 8-MOP.
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