What are the specific photophysical properties of gilvocarcin (GV) that contribute to its high potency?

Label:chem

Topic
The study investigates the photophysical properties of gilvocarcin (GV), including its absorption spectrum, fluorescence emission, and DNA intercalation ability, to understand its high potency in inducing DNA damage.
Answer
Gilvocarcin (GV) has a high extinction coefficient at 398 nm (11971 M^-1 cm^-1), indicating strong absorption of UVA and visible light. Its fluorescence emission is enhanced in the presence of double-stranded DNA, suggesting efficient intercalation. The study also found a self-association constant (K = 4.2×10^5 M^-1) for GV, indicating its tendency to aggregate at higher concentrations. These properties contribute to GV's high potency in inducing DNA damage and inhibiting lymphocyte response.
Return to Home Chemical List
Knowledge you may be interested in
How does gilvocarcin (GV) compare to 8-methoxypsoralen (8-MOP) in terms of potency and mechanism of action? What is the role of gilvocarcin (GV) in inducing DNA damage and its potential application in photochemotherapy? What is the role of GilR in the biosynthesis of gilvocarcin V? How does gamma radiation affect the corrosion behavior of copper in the presence of Ag/AgCl quasi-reference electrodes (QREs)? What is the significance of the AgCl coating on the stability of Ag/AgCl quasi-reference electrodes (QREs) under gamma radiation? How does gamma radiation affect the stability of Ag/AgCl quasi-reference electrodes (QREs)? What is the role of silver/silver chloride (Ag/AgCl) quasi-reference electrodes (QREs) in electrochemical measurements under gamma radiation for corrosion studies? What is the antibacterial activity of Ag/AgCl nanoparticles synthesized with different sugar ligands against multidrug-resistant Escherichia coli? How does the presence of chloride ions affect the interaction between L-Arginine and silver ions during the synthesis of Ag/AgCl nanoparticles? How does the presence of L-Arginine affect the synthesis and properties of Ag/AgCl nanoparticles when using sugar ligands? How does the one-pot HPLC method enable the simultaneous quantification of hydrogen peroxide and organic peroxides? Why is it important to differentiate between hydrogen peroxide and organic peroxides in pharmaceutical and food industries? What is the significance of using hydroxydi-p-tolylborane in the one-pot HPLC method? What are the implications of the hydrogen peroxide and organic peroxide content in pharmaceutical excipients and food samples? What are the effects of hydrogen peroxide on slow- and fast-growing NIH/3T3-derived cultures in relation to cellular senescence and transformation? What is the role of hydrogen peroxide (H₂O₂) in the photodegradation of polyethylene terephthalate (PET) and its monomers bis(2-hydroxyethyl)terephthalate (BHET) and terephthalic acid (TPA)? What is the extent of mineralization achieved in the degradation of TPA and BHET using excimer lamps and hydrogen peroxide? What is the role of copper sulfate pentahydrate (CSP) in the preparation of nitrile butadiene rubber (NBR)/clay nanocomposites? How does the curing time affect the mechanical properties of NBR/clay/CSP nanocomposites? What is the significance of clay in the NBR/clay/copper sulfate pentahydrate (CSP) nanocomposites?