How does disulfiram's cytotoxic activity compare between leukemia cells and other cell types?

Label:chem

Topic
Disulfiram has shown cytotoxic effects. The study compared its impact on different cell lines.
Answer
Acute leukemia cell lines demonstrated significantly higher sensitivity to disulfiram compared to cell lines derived from solid cancers or non-malignant cells. Disulfiram achieved a 50% reduction in viability (IC 50 ) in leukemia cell lines with values ranging from 45 to 81 nM, and 100 nM of the drug decreased the viability of all tested leukemia cell lines to below 20%.
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