How does disulfiram influence the concentration of reactive oxygen species (ROS) within cells?

Label:chem

Topic
Disulfiram is capable of altering the intracellular environment. ROS are generated by cells and can cause oxidative stress.
Answer
Disulfiram can alter the intracellular environment by directly or indirectly manipulating the concentration of reactive oxygen species (ROS). The chelation reaction between DDTC and metal ions is thought to trigger the release of ROS within a cell, potentially causing cellular damage or death. Additionally, some studies have identified antioxidant properties of disulfiram that are protective against the generation or dissemination of ROS, ultimately potentially reducing inflammation by scavenging oxygen radicals from the intracellular environment.
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