What is the role of the disulfide bond in disulfiram's mechanism of action?

Label:chem

Topic
Disulfiram contains a disulfide bond and can react with proteins.
Answer
Disulfiram contains a disulfide bond that is readily reduced by the free sulfhydryl groups of proteins via the thiol-disulfide exchange reaction. This irreversible reaction covalently modifies cysteine residues on target enzymes, causing the inhibition of the enzymatic function and resulting in the release of a DDTC molecule. This mechanism has been proven to inhibit several enzymes, including aldehyde dehydrogenase, methyltransferase, urease, and kinase.
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