How does Ergothioneine improve healthspan and physical performance in aged animals?

Label:chem

Topic
Ergothioneine, a dietary thione/thiol, has shown promise in promoting healthy aging and improving metabolic resilience by enhancing lifespan, mobility, stress resistance, and physical performance in aged animals.
Answer
Ergothioneine (ET) acts as an alternative substrate for cystathionine gamma-lyase (CSE), an H2S-producing enzyme. This action stimulates the production of hydrogen sulfide (H2S), which in turn increases protein persulfidation. Specifically, the persulfidation of cytosolic glycerol-3-phosphate dehydrogenase (cGPDH) enhances its activity, leading to a boost in NAD+ levels. These effects, which include increased NAD+ levels, improved exercise endurance, muscle mass, and vascularization, are dependent on CSE and cGPDH, ultimately contributing to the improved healthspan and physical performance observed in aged animals treated with ergothioneine.
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