Did nicotine therapy improve activities of daily living (ADLs), quality of life (QoL), or cognition in PD patients?

Label:chem

Topic
Secondary outcomes measured in the RCTs included ADL performance (UPDRS Part II), QoL (PDQ-39), and cognition (Mattis Dementia Rating Scale).
Answer
Meta-analysis revealed no significant benefits of nicotine therapy on ADLs (pooled SMD = –0.018, 95% CI –0.351 to 0.315, I² = 0%), QoL, or cognition, indicating a lack of efficacy across these non-motor domains.
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