What are the predicted oral absorption and bioavailability characteristics of CGA and CA?

Label:chem

Topic
Oral bioavailability dictates how much active compound reaches systemic circulation and is governed by size, lipophilicity, intestinal permeability and efflux susceptibility.
Answer
Both CGA (MW 354 Da, 5 rotatable bonds) and CA (MW 132 Da, 2 rotatable bonds) satisfy Lipinski and Veber rules. ADMET predictions indicate moderate human intestinal absorption and oral bioavailability. Caco-2 permeability is low (CGA −6.49; CA −4.77), yet neither is a P-gp substrate, minimizing efflux. CA is more lipophilic (logP 1.97) and BBB-permeable, whereas CGA is hydrophilic (logP −0.39) and restricted to peripheral compartments.
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