Does zinc-mediated inactivation compromise the structural integrity of the IAV particle?

Label:chem

Topic
Some virucidal agents disrupt membranes or degrade viral RNA; others leave the virion intact while disabling key proteins.
Answer
No. Reverse-transcription qPCR and RNase-protection assays showed no loss or release of viral RNA after 1 h exposure to 0–10 mM ZnCl₂, indicating that the viral envelope and genome remain intact while HA function is selectively impaired.
Return to Home Chemical List
Knowledge you may be interested in
How do zinc ions affect influenza A virus (IAV) hemagglutinin function and virus infectivity? What role does desloratadine or levocetirizine play when added to oral isotretinoin in the treatment of acne vulgaris? What evidence supports the efficacy of relugolix combination therapy in endometriosis? How do clinical outcomes compare between relugolix monotherapy and combination therapy? Does relugolix combination therapy preserve BMD over extended treatment periods? What strategy has been developed to mitigate relugolix-induced BMD loss? How does relugolix monotherapy affect bone mineral density (BMD)? What is relugolix, and how does it function as a therapeutic agent in uterine diseases? Does combining diazepam with low-frequency rTMS produce additive or synergistic suppression of Ca²⁺ elevation? What is diazepam’s pharmacological role in modulating epileptiform activity, and at what concentration was it tested? Is the antiviral activity of zinc ions maintained across physiologically relevant temperatures? What is Cucurbitacin E (CuE) and where is it derived from? Does Cucurbitacin E (CuE) exhibit cytotoxicity toward 3T3-L1 adipocytes during adipogenesis? How does CuE influence lipid accumulation in differentiating 3T3-L1 adipocytes? Which key adipogenic transcription factors are down-regulated by Cucurbitacin E (CuE)? What molecular pathways are implicated in CuE-mediated inhibition of adipogenesis and lipogenesis? What is the overall conclusion regarding CuE’s potential as an anti-obesity agent? What is the role of synthetic angiotensin II (Giapreza®/AT2S) in the peri-operative management of kidney transplantation? Were there any safety concerns specific to angiotensin II (Giapreza®/AT2S) use? What is nicotine's proposed mechanism of neuroprotection in Parkinson’s disease (PD)?