What is the primary function of serotonin (5-HT) in the context of the intratumoral serotonin axis?

Label:chem

Topic
Serotonin is a signaling molecule.
Answer
In the intratumoral serotonin axis, tryptophan hydroxylase 1 (TPH1) converts tryptophan (Trp) into serotonin (5-HT), which is then secreted into the tumor microenvironment (TME) to stimulate T cells by binding to their surface 5-HT receptors (5-HTR).
Return to Home Chemical List
Knowledge you may be interested in
How do Selective Serotonin Reuptake Inhibitors (SSRIs) impact tumor growth and T cell antitumor immunity? What is the role of Serotonin Transporter (SERT) in antitumor immunity? Why is phenobarbital considered an alternative to benzodiazepines for severe alcohol withdrawal, and what are its pharmacological advantages? What is Perampanel, and what is it used for? What are the characteristics of Copper Oxide (CuO)? What are the properties of Nickel Oxide (NiO)? Why is Phenobarbital considered a critical compound in forensic medicine? What is the therapeutic concentration range for Phenobarbital (PB)? Why is accurate monitoring of Phenobarbital (PB) recommended? What are the side effects of long-term Phenobarbital (PB) use? What is the role of Monoamine Oxidase A (MAO-A) in the intratumoral serotonin axis and why are its inhibitors not preferred for cancer immunotherapy despite enhancing antitumor immunity? What is 5-HTP, and how does it affect serotonin levels? What is fenfluramine, and how does it affect serotonin levels? What is escitalopram, and how does it affect serotonin levels? How did 5-HTP affect the acquisition and expression of conditioned fear in rats? How did fenfluramine affect the acquisition and expression of conditioned fear in rats? How did escitalopram affect the acquisition and expression of conditioned fear in rats? How does serotonin promote lip sensory recovery after inferior alveolar nerve transection? What is the effect of GK921 on axonal growth and lip sensory recovery after inferior alveolar nerve transection? Why are serotonin neurons important in mental disorders?