What is the effect of GK921 on axonal growth and lip sensory recovery after inferior alveolar nerve transection?

Label:chem

Topic
GK921 is a transglutaminase 2 inhibitor. One study used GK921 to inversely verify the effect of serotonin on neural growth.
Answer
GK921 significantly reduced axonal length and delayed lip sensory recovery after inferior alveolar nerve transection by decreasing histone serotonylation and diminishing the production of neurotrophic factors, thus hindering nerve regeneration.
Return to Home Chemical List
Knowledge you may be interested in
How does serotonin promote lip sensory recovery after inferior alveolar nerve transection? How did escitalopram affect the acquisition and expression of conditioned fear in rats? How did fenfluramine affect the acquisition and expression of conditioned fear in rats? How did 5-HTP affect the acquisition and expression of conditioned fear in rats? What is escitalopram, and how does it affect serotonin levels? What is fenfluramine, and how does it affect serotonin levels? What is 5-HTP, and how does it affect serotonin levels? What is the role of Monoamine Oxidase A (MAO-A) in the intratumoral serotonin axis and why are its inhibitors not preferred for cancer immunotherapy despite enhancing antitumor immunity? What is the primary function of serotonin (5-HT) in the context of the intratumoral serotonin axis? How do Selective Serotonin Reuptake Inhibitors (SSRIs) impact tumor growth and T cell antitumor immunity? Why are serotonin neurons important in mental disorders? Why is glucose a favored carbon source in E. coli culture? What is the multipurpose nature of glycerol in the synthesis of silver nanoparticles? What are the multiple applications of silver nanoparticles synthesized in glycerol? How does the selective hydrogenation of 4-nitrophenol to 4-aminophenol proceed when catalyzed by silver nanoparticles? What are the characteristics of the silver nanoparticles synthesized using glycerol? What are the roles of PVP and NaOH in the polyol synthesis of silver nanoparticles in glycerol? How effective are the silver nanoparticles synthesized in glycerol as antibacterial agents against E. coli and S. aureus? What is the nature of glycerol adsorption on the K₂O (110) surface, and how does it impact the surface? Why are glycerol and sorbitol considered promising alternative fuels for fuel cells?