How do Selective Serotonin Reuptake Inhibitors (SSRIs) impact tumor growth and T cell antitumor immunity?

Label:chem

Topic
SSRIs are a class of antidepressants that block SERT.
Answer
SERT-blocking Selective Serotonin Reuptake Inhibitors (SSRIs) enhance CD8 T cell antitumor immunity and significantly suppress tumor growth. They can also synergize with anti-PD-1 treatment, positioning them as potential cancer immunotherapeutics.
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