What is the role of Serotonin Transporter (SERT) in antitumor immunity?

Label:chem

Topic
SERT is a regulator of serotonin levels.
Answer
Serotonin Transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. It acts as an immune checkpoint restricting CD8 T cell antitumor immunity, and its intratumoral expression is linked to poor patient survival.
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