What is phenobarbital used for in neonatal cholestasis?

Phenobarbital (PB) is a long-acting barbiturate that is commonly used to treat neonatal jaundice. It works by enhancing the liver's drug metabolism and promoting bilirubin metabolism.

Phenobarbital (PB) is used in the treatment of neonatal jaundice because it can enhance the liver's drug metabolism, promote bilirubin metabolism, and ultimately reduce plasma bilirubin concentration, thereby achieving an anti-jaundice effect. It can also induce hepatic drug enzymes, which can promote the effects of other medications when used in combination.