What is the significance of amide bonds in pharmaceutical compounds?

Label:chem

Topic
Amide bonds are ubiquitous in nature, structuring biomacromolecules such as proteins and playing a major role in their biological activities. They are involved in numerous interactions (e.g., hydrogen bonding or electrostatic interactions) related to biological processes. Amide bonds are also present in a large number of manufactured molecules, including materials and pharmacologically active compounds. In fact, 25% of active pharmaceutical ingredients (APIs) possess an amide bond.

From: "Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide", Chem. Commun., 2023,59, 3439-3442
Answer
Amide bonds are crucial in pharmaceutical compounds as they contribute to the structural integrity and biological activity of many APIs. Their presence in a significant portion of marketed drugs highlights their importance in drug design and function.
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