Does lisinopril affect the metabolic rate of Drosophila melanogaster with Alzheimer's disease-like symptoms?

Label:chem

Topic
ACE inhibitors have been shown to have neuroprotective properties in Alzheimer's disease (AD) models. This study investigates whether lisinopril affects the metabolic rate of Drosophila melanogaster with AD-like symptoms, which could provide insights into the potential therapeutic effects of lisinopril in neurodegenerative diseases.
Answer
Lisinopril significantly increases the whole-body metabolic rate in young flies with AD-like symptoms, but not in old flies. This suggests that lisinopril may have therapeutic potential in improving metabolic function in younger individuals with AD-like symptoms. The findings support the idea that ACE inhibitors could play a role in modulating metabolic processes in neurodegenerative diseases, potentially through mechanisms involving the renin-angiotensin system.
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