How does the ACE inhibitor lisinopril affect the metabolic rate in Drosophila melanogaster?

Label:chem

Topic
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used to treat hypertension and manage heart failure. It has also been shown to influence metabolic processes, potentially through enhanced fat oxidation and improved insulin sensitivity. This study investigates the effects of lisinopril on the metabolic rate in Drosophila melanogaster, a model organism with genetic and metabolic similarities to humans.
Answer
Lisinopril affects the whole-body metabolic rate in Drosophila melanogaster in a genotype-, sex-, and age-dependent manner. The effects are highly context-dependent, influenced by genetic background, sex, and age. Lisinopril may increase the metabolic rate through the accumulation of a bradykinin-like peptide, which enhances cold tolerance by upregulating Ucp4b and Ucp4c genes. The effect of lisinopril also depends on the expression of Ance, the ortholog of mammalian ACE, in the Malpighian/renal tubules and the nervous system. In summary, lisinopril modulates metabolic rate through mechanisms involving both the reduction of Angiotensin II-equivalent signaling and the accumulation of bradykinin-like peptides.
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