What is the role of Ance in modulating the metabolic rate in Drosophila melanogaster?

Label:chem

Topic
Drosophila melanogaster has two homologs of human ACE, namely Ance and Acer. Ance is inhibited by lisinopril through a similar mechanism as in humans. This study investigates the role of Ance in modulating metabolic rate in Drosophila melanogaster by knocking down Ance expression in specific tissues.
Answer
The effect of lisinopril on whole-body metabolic rate depends on Ance expression in the Malpighian/renal tubules and the nervous system. Knocking down Ance in these tissues results in significant changes in metabolic rate, with the effects being sex- and age-specific. In the Malpighian tubules, Ance knockdown leads to a significant decrease in metabolic rate in both female and male flies, independent of age. In the nervous system, Ance knockdown results in a significant increase in metabolic rate in young flies, independent of sex. These findings suggest that Ance plays a critical role in modulating metabolic rate in Drosophila melanogaster through tissue-specific mechanisms.
Return to Home Chemical List
Knowledge you may be interested in
How does the ACE inhibitor lisinopril affect the metabolic rate in Drosophila melanogaster? What is the tautomeric behavior of the synthesized thiophenes and thiazoles, and how does it affect their structural properties? How do cyanothioacetamides react with dimethyl acetylenedicarboxylate (DMAD) to form thiophenes and thiazoles, and what factors influence the product distribution? How do endogenous hormone levels change in rubber trees treated with GA3 and CCC? How does the gibberellin (GA) biosynthesis inhibitor chlormequat chloride (CCC) affect flowering in rubber trees? What is the role of gibberellin (GA) in the regulation of flowering in rubber trees (Hevea brasiliensis)? What is the effect of exogenous gibberellin application on leaf-flush growth, morphometry, and delayed phenology in post-pruning kaffir lime seedlings? What are the transcriptional changes induced by GA3 treatment in Lomatogonium rotatum seeds during germination? What are the optimal conditions for GA3 treatment to enhance seed germination in Lomatogonium rotatum? How does GA3 treatment affect the embryo development of Lomatogonium rotatum seeds? How does lisinopril influence cold tolerance in Drosophila melanogaster? Does lisinopril affect the metabolic rate of Drosophila melanogaster with Alzheimer's disease-like symptoms? What is the role of the FeCu/NC catalyst in the electro-Fenton degradation of lisinopril (LSN)? How does the FeCu/NC catalyst compare to monometallic catalysts (Fe/NC and Cu/NC) in the electro-Fenton process for lisinopril degradation? What are the main by-products of lisinopril degradation in the FeCu/NC-catalyzed electro-Fenton process? What is the role of meta-Topolin (mT) in the in vitro propagation of sweet potato (Ipomoea batatas)? How does the combination of meta-Topolin (mT) with other plant growth regulators affect shoot multiplication in sweet potato? What is the effect of meta-Topolin (mT) on the genetic integrity of in vitro propagated sweet potato plants? How does Indole-3-butyric acid (IBA) affect root induction in in vitro propagated sweet potato shoots? What is the role of meta-topolin in the in vitro multiplication and quality improvement of Húsvéti Rozmaring apple scion shoots?