How does lisinopril influence cold tolerance in Drosophila melanogaster?

Label:chem

Topic
ACE inhibitors like lisinopril have been shown to increase bradykinin levels, which are involved in thermoregulation and cold tolerance in mammals. This study investigates whether lisinopril affects cold tolerance in Drosophila melanogaster by measuring chill-coma recovery time (CCRT) and the expression of uncoupling protein (UCP) genes.
Answer
Lisinopril improves cold tolerance in Drosophila melanogaster in a genotype-, sex-, and age-specific manner. Specifically, lisinopril-treated DGRP_367 young males and DGRP_808 old males exhibited significantly faster recovery from chill-induced coma compared to untreated males. The expression of Ucp4b and Ucp4c genes, which are involved in cold-induced thermogenesis, was significantly increased in the heads of lisinopril-treated DGRP_367 young male flies. This suggests that lisinopril enhances cold tolerance through the induction of UCPs, similar to the mechanism observed in mammals.
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