Why have previous attempts with engineered bacteria expressing uricase shown limited efficacy in reducing serum uric acid concentrations for hyperuricemia management?

Label:chem

Topic
Engineered bacteria expressing uricase were developed to increase uric acid breakdown in the intestines. However, their effectiveness in reducing serum uric acid levels has been limited, possibly because the anaerobic environment of the intestines reduces uricase activity.
Answer
The limited efficacy of engineered bacteria expressing uricase in diminishing serum uric acid concentrations is primarily attributed to the anaerobic environment of the intestines, which can attenuate uricase activity.
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