Why was a new poly(methyl methacrylate) (PMMA)-based conjugate developed?

Label:chem

Topic
The field of total dental prostheses primarily uses poly(methyl methacrylate) (PMMA) as the denture base material. However, a significant limitation is the inadequate fixation of total dentures to the buccal gingiva, which necessitates patients to use adhesive pastes at least twice daily. This current regimen is both costly and reduces patient comfort.
Answer
A new poly(methyl methacrylate) (PMMA)-based conjugate was developed to enhance its mucoadhesive features for gingiva. This modification aims to provide a potential long-term total denture base material, leading to more patient-friendly prostheses by improving adhesion and overcoming the limitations of existing materials. The development involved synthesizing MMA-based conjugates with varying amounts of hydroxyethyl maleimide (HEM) and poly(ethylene glycol) (PEG), and subsequently characterizing their mucoadhesive properties and assessing their toxicity.
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