What is nicotine's proposed mechanism of neuroprotection in Parkinson’s disease (PD)?

Label:chem

Topic
Epidemiological studies show an inverse association between smoking and PD risk, prompting interest in nicotine as a therapeutic agent.
Answer
Nicotine activates nicotinic acetylcholine receptors, enhancing dopamine release, reducing oxidative stress, inhibiting neuroinflammation, and stimulating pro-survival signaling pathways (PI3K/Akt and ERK) that support mitochondrial function and suppress α-synuclein aggregation.
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