How effective are the silver nanoparticles synthesized in glycerol as antibacterial agents against E. coli and S. aureus?

Label:chem

Topic
The antibacterial activity of AgNPs has been widely demonstrated against both gram-negative (E. coli) and gram-positive (S. aureus) bacterial strains. Silver ions discharged from nanoparticles are vital to such activities. Silver ions disrupt DNA replication and produce oxygen free radicals harmful to microorganisms. Smaller, spherical nanoparticles release silver ions more efficiently. Using the ZOI method, AgNPs indicated good antibacterial performance against both E. coli (16.9 ± 0.1 mm diameter) and S. aureus (20.0 ± 0.1 mm diameter). The MIC method showed that AgNPs effectively inhibited growth at high concentrations. Compared to E. coli, AgNPs showed superior antibacterial action against S. aureus, with a lower MIC value for S. aureus (3.4 ppm) compared to E. coli (6.8 ppm).
Answer
Silver nanoparticles (AgNPs) synthesized in glycerol demonstrated good antibacterial performance against both E. coli and S. aureus strains. They effectively inhibit microbial growth, with superior action against S. aureus (MIC of 3.4 ppm) compared to E. coli (MIC of 6.8 ppm). This activity is attributed to silver ions disrupting DNA replication and producing harmful oxygen free radicals.
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